Halloween Costume ideas 2015
April 2017

New Delhi 
Shraddha Kapoor, who is currently busy shooting for her upcoming biopic ' Haseena,' got a surprise from her teammates for crossing 15 million followers on Instagram.

The 30-year-old-actress took to Instagram and shared a video of her teammates surprising her by bringing a cake to celebrate this special feat.

She captioned the video, "They surprised me!!! Love my team so so much and love all of you out here!!!! Thank you all for the 15 m."
The cake had a cute message written on it which stated, "Agah Bai, 15 Million Followers."
On the work front, Shraddha Kapoor will be next seen in Mohit Suri's ' Half Girlfriend,' alongside Arjun Kapoor.

New Delhi
The latest version of U-Dictionary Android app (v 2.6.1) now allows you to just Copy an English Word in a WhatsApp message and instantly get the meaning in your native language via Tap to Translate feature.

This feature works vice versa as well; you can copy a Word in any of the 10 Indian languages supported by U-Dictionary in a WhatsApp message and instantly get the meaning in English. The best part is that Tap to Translate feature works great Offline too.

Several cool new features such as Picture dictionary, Sample Sentences Offline and Phrases have also been added to the latest version. Picture dictionary makes it easier for you and your family members of any age to understand the Word Meaning. Sample Sentences Offline provides offline download of sample sentences, from internationally reputed news sources such as BBC, to help you quickly understand the usage of the word. Lastly, Phrases cements your understanding of a new Word, by helping you learn the usage of the Word in phrases and other advanced cases.

According to Kshitij Kumar Parashar, Head of South Asia Marketing for U-Dictionary, "The major advantage of U-Dictionary app over other apps is that it can show various definitions clearly at a relatively smaller size. This addresses the key concern of data savvy users who can use the app with less data online and less space offline."

U-Dictionary is a lightweight app which is suitable for all smartphone users, however, those who prefer to learn on a PC at the comfort of their home, can now browse U-Dictionary on the web. All the pictures and articles are moderated and carefully articulated, so it's safe to open the website at Work.

U-Dictionary has a dedicated team of linguistic, design and development experts who are working together for the sole purpose of making your learning experience the best. The Team has been consistently coming up with different creative new features to address the unmet needs of users and enhancing the existing ones.

U-Dictionary helps users from all categories, be it students, tourists, or English learners and helps everyone regardless of language boundaries. Anybody can use this app as a great tool for learning English from different languages. It has been awarded as "Best Self Improvement App of 2016" by Google Play. 

triple talaq, triple talaq issue, Narendra Modi, PM Modi on triple talaq, Congress PM Modi, BJP, BJP triple talaq, Ghulam Nabi azad, Ghulam nabi azad PM Modi, Ghulam nabi azad triple talaq, india news, indian epxress news
New Delhi
The Congress on Saturday accused the Prime Minister and the BJP of politicising the triple talaq issue and even suggested that the saffron party was trying to drive a wedge between Muslim women and their husbands to create a new vote bank. Senior Congress spokesperson Ghulam Nabi Azad said no other political party except the BJP and its ideological mentor the RSS are trying to politicise the issue.
The Leader of Opposition in Rajya Sabha said no Muslim believes in triple talaq and the practice is adhered to as per the holy book in which certain norms and time-frame have been laid.
“When the society is already discussing this issue of triple talaq and the court is looking into it, then why is the BJP unnecessarily coming in between Muslim women and their Muslim husbands. The BJP should not make attempts at creating a new vote bank,” he told reporters.
Asked about Prime Minister Narendra Modi’s statement today urging Muslims not to view the issue of triple talaq from political perspective, he alleged that it was the Prime Minister who was politicising the issue.
“He is the biggest champion of politicising the issue. He is the champion and he started it. And to say not to politicise it, is itself politicising it,” he said, adding that the Prime Minister should exercise restraint and rein in his partymen.
Azad asked if any other political party was seen raising the issue except BJP and RSS. He said if any other leader was saying so, it was only in response to what the BJP is saying.
“BJP leaders and the RSS have been making this a political agenda before and during the elections. This is the agenda of the BJP and the RSS to politicise it. Other parties have only responded,” he said.
Azad said he does not think any Muslim believes in misusing triple talaq as “it is against Shariyat, Quran and Islam”.
“BJP is politicising triple talaq. It is illegal, as it does not stand in religion or in the Quran. Talaq is a long drawn process and time frame has been given and Muslims go by it,” he said.

He said no Muslim believes in triple talaq in one go and added that for thousands of years, ills and infirmities in various religions have existed and are corrected with time. He also cited the social evil of Sati among Hindu women which have been eradicated over time.
“People have made many interpretations and there have been several changes. Whatever is good remains and others are removed,” he said.
Modi today urged Muslims not to view the triple talaq issue from a political perspective and expressed the confidence that efforts to end the practice would be led by “enlightened” members of the community.
At a function to mark the Basava Jayanti celebrations in honour of Kannada philosopher Basaveswara, Modi referred to the 12th century reformer’s movement against regressive practices to speak about triple talaq.

WASHINGTON 
The White House press corps gathered Saturday for its annual black-tie dinner, a toned-down affair this year after Donald Trump snubbed the event, becoming the first incumbent U.S. president to bow out in 36 years.

Without Trump, who scheduled a rally instead to mark his 100th day in office, the usually celebrity-filled soiree hosted by the White House Correspondents’ Association took a more sober turn, even as it pulled in top journalists and Washington insiders.

Most of Trump’s administration also skipped the event in solidarity with the president, who has repeatedly accused the press of mistreatment. The president used his campaign-style gathering to again lambaste the media.

“I could not possibly be more thrilled than to be more than 100 miles away,” he told a crowd in Harrisburg, Pennsylvania, calling out The New York Times, CNN and MSNBC by name.


In Washington, WHCA President Jeff Mason defended press freedom even as he acknowledged this year’s dinner had a different feel, saying attempts to undermine the media was dangerous for democracy.

“We are not fake news, we are not failing news organizations and we are not the enemy of the American people,” said Mason, a Reuters correspondent.

Instead of the typical roasts — presidents of both parties have delivered their own zingers for years — the event returned to its traditional roots of recognizing reporters’ work and handing out student scholarships as famed journalists Bob Woodward and Carl Bernstein presented awards.

“That’s not Donald Trump’s style,” NBC News’ Andrea Mitchell told MSNBC, referring to the self-deprecating jokes presidents in the past have made despite tensions with the press.

Instead, the humor fell to headline comedian Hasan Minhaj.
“We’ve got to address the elephant that’s not in the room,” Minhaj, who plays a correspondent on Comedy Central’s The Daily Show, told the crowd. “The leader of our country is not here. And that’s because he lives in Moscow. It’s a very long flight. As for the other guy, I think he’s in Pennsylvania because he can’t take a joke.”

He also joked about Trump, despite organizers’ wishes, saying he did so to honor U.S. constitutional protection of free speech: “Only in America can a first-generation, Indian-American Muslim kid get on this stage and make fun of the president.”

Trump in Pennsylvania

Trump was indeed in Pennsylvania, having scheduled a rally in Harrisburg to mark his 100th day in office. He began his remarks with a lengthy if familiar attack on the news media while dismissing the dinner and its participants.

“A large group of Hollywood actors and Washington media are consoling each other in a hotel ballroom in our nation’s capital right now,” Trump said. He added: “And I could not possibly be more thrilled than to be more than 100 miles away from Washington’s swamp, spending my evening with all of you and with a much, much larger crowd and much better people, right?”

Trump became the first president since Ronald Reagan in 1981 to skip the event — and Reagan was recovering from an assassination attempt.

In a video message, actor Alec Baldwin, who has raised Trump’s ire playing him on NBC’s “Saturday Night Live” program also encouraged attendees.

Fewer celebrities

Few other celebrities graced the red carpet, although some well-known Washingtonians, such as former Secretary of State Madeleine Albright and Republican Representative Darrell Issa of California, appeared.

Trump attended in 2011, when then-President Barack Obama made jokes at the expense of the New York real estate developer and reality television show host.

In an interview with Reuters this week, Trump said he decided against attending as president because he felt he had been treated unfairly by the media, adding: “I would come next year, absolutely.”

In Pennsylvania, Trump told supporters the media dinner would be boring but was noncommittal on whether he would go in 2018 or hold another rally.
Late night television show host Samantha Bee also hosted a competing event — “Not the White House Correspondents’ Dinner” — that she said would honor journalists, rather than skewer Trump.

The WHCA awards and this year’s recipients:

  • Aldo Beckman Memorial Award winner: Greg Jaffe of The Washington Post for stories on President Barack Obama’s speeches and policies that contrasted the realities of 2016 with the hopes of 2008.
  • Merriman Smith Award winner for outstanding White House coverage under deadline: Edward-Isaac Dovere of Politico for his coverage of the historic meeting between Obama and Cuban President Raul Castro.
  • Edgar A. Poe Award winner: David Fahrenthold of The Washington Post for stories on Donald Trump’s philanthropic claims.

Reuters

New York
Just weeks after receiving official approval, an Apple self-driving car has been seen making its way through the streets of Silicon Valley.

The Lexus fitted with various sensors is the latest entrant in the quest to make driverless cars commercially viable. Apple, a late comer, likely will face fierce competition from Google’s Waymo, which has carried out millions of miles of road testing, and Uber, which has been testing autonomous cars for months.
Apple’s initiative, officially called Project Titan, is driven by hardware developed by Velodyne Lidar, while Apple is expected to develop the software.

Based on documents obtained by Business Insider, Apple’s cars sound very much like other self-driving cars. The cars are “capable of sending electronic commands for steering, accelerating, and decelerating and may carry out portions of the dynamic driving task,” according to the documents.

As with other driverless cars, humans are still present and can override the self-driving mode at any time.

Despite being somewhat late to the game, Apple may find an opening in the way of a potentially lengthy legal battle between Waymo and Uber, with Waymo alleging that Uber stole its trade secrets.

On Thursday, Uber executive Anthony Levandowski recused himself from work on driverless cars in the wake of the lawsuit, which alleges he stole intellectual property while employed at Google.

New York 
Stressing on the importance of unity between Muslims and Christians to shape world peace, Pope Francis on Friday urged to reject violence in the name of God or religion and preach messages of peace and tolerance instead.
"Let us say once more a firm and clear 'No!' to every form of violence, vengeance and hatred carried out in the name of religion or in the name of God," reported CNN, quoting the Pope said at a peace conference at Al-Azhar University, the premier seat of high learning among Sunni Muslims.

The pope said it is essential to eliminate poverty and exploitation in order to prevent conflicts and build peace in the world.

"In order to prevent conflicts and build peace, it is essential that we spare no effort in eliminating situations of poverty and exploitation where extremism more easily takes root, and in blocking the flow of money and weapons destined to those who provoke violence," he said.

He also called for an end to the proliferation of arms and condemned demagogic forms of populism.

"If they are produced and sold, sooner or later they will be used. Only by bringing into the light of day the murky maneuverings that feed the cancer of war can its real causes be prevented. National leaders, institutions and the media are obliged to undertake this urgent and grave task." He said.

The Pope arrived in Egypt on Friday, on two-day trip, which is aimed to shape the Muslim-Christian brotherhood.

The Pope's visit comes nearly two weeks after the Palm Sunday attack on two Coptic churches in Egypt, leaving at least 45 people dead. 

New Delhi 
Hollywood stylist Paris Libby, who is known to have a big client list ranging from Liam Hemsworth to Jeremey Renner to Vin Diesel is now gearing up to style the Bollywood fashionista Jacqueline Fernandes, who will be hosting Justin Bieber in India.

The famous hairstylist who has also styled many of Hollywood A-Listers for red carpet and photo shoots, including Sharon Stone, Miley Cyrus, Zoe Saldana and Britney Spears is excited to come to India and is a huge fan of Indian culture and design.

He said, "Mumbai is a home to great style and I am excited to be coming back yet again. I am a huge fan of Indian culture and design. On this trip I wish to meet a few directors and designers."

While, the 31-year-old-actress revealed about the looks she is going to be in during the much-awaited Justin Bieber concert.

"Yes it's true. We have handpicked 3 key looks with a mix of contemporary and ethnic designs. I briefly met Paris during the ' XXX- Return Of Xander' press tour in India and we connected instantly," said Jacqueline Fernandez.

Paris Libby will be joining Burberry model Neelam Gill and Harry Potter Half Blood Prince actress Elarica Johnson as part of the international entourage attending the highly anticipated Justin Bieber Purpose Tour and the line-up just seems to be getting more impressive!

The Purpose World Tour has already mesmerised fans and critics alike across the United States, Canada and Japan last year and will tour throughout Europe before landing in Australia and New Zealand this year.

White Fox India will be bringing the 23-year-old Canadian megastar's Purpose World Tour to India's DY Patil Stadium, Mumbai on May 10.

New Delhi
NITI Aayog Vice-Chairman Arvind Panagariya on Friday categorically stated that there is no question of taxing agriculture income at a time when the government is keen on doubling the income of farmers.
"80 per cent of rural areas are connected to agriculture and we are talking about doubling farmers' income. How can we talk about taxing farmers income?" Panagariya told reporters on the sidelines of a CII function.

He was responding to a question on controversial remark on taxing farm income made by NITI Aayog member Bibek Debroy.

"There is nothing of taxing agriculture income... in the document," Panagariya said, adding that the nearest thing that was mentioned in the 3-year action agenda was loopholes should be plugged to prevent non-agriculturists from converting their black money into white by showing it as agriculture income.

On farm loan waiver, the NITI Aayog vice-chairman said, "States are empowered to waive farm loan... Besides their priorities, states are bound by the FRBM Act."

A controversy had erupted after Debroy at a press conference said the agricultural income should be taxed.

However, Finance Minister Arun Jaitley later clarified that there was no such proposal and the Centre has no power to impose tax on agricultural income.

The NITI Aayog too quickly distanced itself from the comment, saying it was the personal view of Debroy and there was no proposal in the 3-year action agenda, which was circulated among the chief ministers on Sunday, to tax farm income.

New Delhi
Prime Minister Narendra Modi and Cyprus President Nicos Anastasiades on Friday strongly pitched for decisive action against states supporting, sheltering and sustaining "violence factories" in their regions.
The two leaders held detailed discussion on bilateral as well as regional and international issues of mutual concern. These included ways to boost trade ties and UN Security Council reforms.

Both sides also signed four pacts, including one for air services and another on cooperation in merchant shipping.

At a joint media event with the Cypriot leader, Modi said India has always stood with Cyprus on crucial issues and firmly supports its sovereignty, unity and territorial integrity.

Modi said India has contributed personnel to the UN Peacekeeping Force (UNPKF) in Cyprus.

Three force commanders from India, Modi said served in Cyprus as a part of the UNPKF and are fondly remembered in the Mediterranean country. He also lauded the Cypriot President's efforts to resolve the long-pending Cyprus issue. 

Anastasiades said he is sincerely appreciative of his "dearest friend" Modi and the Indian government for India's equivocal support on the Cyprus issue.

Modi said that while India has been battling cross-border terrorism for decades, Cyprus, due to its geographical location, understood the threat posed by terrorism.

"We agreed that there is an urgent need for all countries to decisively act against those states which generate, support, shelter and sustain these factories of violence in our regions," the prime minister said in a veiled reference to Pakistan.

Emphasising the need for creating a comprehensive legal framework to fight terror, Modi advocated early conclusion of the Comprehensive Convention on International Terrorism, proposed by India at the UN.

The two sides also agreed on the need for early reforms in the UNSC as Modi expressed appreciation for Cyprus' support to India's bid for inclusion in the world body as a permanent member.

The Cypriot leader said his country wanted India to become a member of the Nuclear Suppliers Group.

Describing the Cypriot president as "great friend and strong supporter of India", Modi said he also discussed with him ways to strengthen the partnership in other "inter- governmental organisations and regimes".

Issues like growing economic relations between India and Cyprus figured during the talks.

The Mediterranean country is the eighth largest investor in India. Last year, the two countries had revised the double taxation avoidance agreement.

For better coordination between the two countries in key sectors, Anastasiades also announced an inter-ministerial working group to provide "much needed political direction".

The Cypriot president said his country is supportive of enhancement of the EU-India strategic partnership and back a EU-India free trade agreement.

Anastasiades invited Indian companies to invest in Cyprus which can help them gain an easy access to Europe, the Gulf region and North Africa.

Earlier, External Affairs Minister Sushma Swaraj called on the Cypriot president, and discussed areas of bilateral cooperation.

New Delhi
The Supreme Court on Friday ordered the police to detain a man forthwith for not depositing the money he had promised in the last hearing, saying no one can “run away” after making a statement in the court. “When you have made a statement to the court, you cannot run away. Have you made a statement? The answer is yes. Have you complied with it? The answer is no. We do not need anything more,” a bench headed by Chief Justice J S Khehar said

Warsaw, Poland
Vice President M. Hamid Ansari has said that terrorism has become a pandemic and affects every society. He was addressing the Media onboard Air India One Special Aircraft while returning to India concluding five-day visit to Armenia and Poland. The Minister of State for Micro, Small & Medium Enterprises, Giriraj Singh and other dignitaries were present on the occasion. 

The Vice President said that both Armenia and Poland were very friendly countries and we were able to regenerate interest in mutual cooperation. Though Armenia is a small country, it has traditionally been very friendly to us, he added. 

Referring to Poland, the Vice President said that it is the biggest economy in Central Europe and we have an expanding trade with them. He further said that there are Indian investments in Poland and Polish investments in India and during the course of discussions, with both the Polish President and the Prime Minister, we were able to identify some specific areas where cooperation between these two countries is either starting or can start very soon. We were able to focus on three particular areas of interest; clean coal mining technology, agricultural products and techniques and defence cooperation, he added. 

The Vice President said that he had suggested to the Polish leadership for Poland to join the Make in India Programmes and instead of being a seller only, they could become an India based seller, which will give them a much additional advantages. He further said that the Polish side reacted very positively to the suggestion and there will be substantial progress in coming day when the Polish President visits India. All in all, the discussions were very focused and very positive and in both countries, the results have been satisfactory, he added. 

Reacting to a question on exploring potential with Armenian innovation and Indian efforts coming together for mutual benefit, the Vice President said that Armenian innovation is good and Indian effort is right in its place. We need to see where and what the innovation is and where it will fit in to our requirements, he added. 

On a question about the road ahead in our relationship with Poland, the Vice President said that Poland has done its own homework in identifying India's rising profile to become a major trading partner and a major political entity in its own right. He further said that the Poles have identified a few markets in Asia as priority markets and India is one of them. We both look forward and expect several initiatives in furthering this process, he added. 

Answering a question on adopting Comprehensive Convention on International Terrorism (CCIT), the Vice President said that every country is facing the problem of terrorism in a lesser or greater degree and the problem is understood by everyone. He referred to the time when he was the permanent representative of India to UN in New York in 1994, when India had introduced a proposal on CCIT and it was struck because there was a difference in perception with regard to defining a terrorist. He further said that while making an international agreement, all kinds of legal problems come up and those who do not want this to make progress, come up with legal technicalities. It is an excuse on part of some countries to try to avoid committing themselves, he added. 

Reacting to a question on image of India in foreign countries, the Vice President said that India's image outside, or image within the country is on different planes and multiple images are a fact of life. He referred to India, through ISRO, sending Mars mission and launching satellites of several countries. He further said that a common man looks at our strengths in Information Technology and Indian IT professionals are present all over the world and as long as the picture is a faithful one, we have to take note what ISRO is doing, what IT is doing and what Indian scientific research is doing. Along with it, there is poverty, there is inequality, but despite all this is also the fact that we have been able, for seven decades, to run a democratic system on a monumental scale, he added. 

Stuttgart
Maria Sharapova marked her return from a 15-month doping ban on Wednesday with a rusty 7-5, 6-3 win over Roberta Vinci in Stuttgart, describing victory as the "best feeling in the world".

Sharapova, the former world number one and five-time Grand Slam champion, brushed off a nervous start to eventually claim a convincing win on her controversial comeback having tested positive for meldonium at the 2016 Australian Open.

"It's the best feeling in the world to walk out (on court), it's been a stage of mine since I was a young girl and it was very special," said Sharapova who celebrated her win with a succession of double fist pumps and a broad smile before blowing kisses to all corners of the Porsche Arena.
"I have been waiting for this a long time."

Sharapova was given a wildcard to play in Stuttgart, where she has been champion three times, a move which drew a barrage of criticism from rivals who believed she was receiving preferential treatment.

She fired 39 winners and 11 aces past 34-year-old Vinci, one of many to have voiced her concerns over the Russian benefitting from wildcards.

After receiving warm applause from the crowd, which included one fan who held up a Russian flag bearing the words 'Welcome back Maria', Sharapova, dressed in an orange top and lilac-coloured dress, initially struggled.

She quickly found herself 2-0 down before she broke back to level at 2-0.

As was to be expected after her long break, Sharapova laboured to find her shots and Vinci profited from several mistakes.

But the 30-year-old Russian started to move her Italian opponent around the court and found her range with a pair of aces.

Sharapova finally broke the Italian in the 11th game and then held her service, converting her second set point in exactly an hour.

Vinci had lost to Sharapova in both their previous meetings and the Italian trailed from 2-0 down in the second set on Wednesday.

Sharapova quickly moved to 5-3 ahead up with an ace and extended her domination in the following game, racing into a 40-0 lead and converted her first match point for victory in one hour, 45 minutes.

"I've been doing this for so long and this was my first match for a while, so when you are in the moment, you block everything else out," said Sharapova.

"I'm competitive by nature, even when things aren't working out.

"That's when I am at my best, when I forget about everything, just be me and just compete."

Sharapova will now play fellow Russian Ekaterina Makarova in Thursday's second-round.

"It's going to be tough, but every match I play now is important for me," she said.

"It's important to just play, it's a journey and it officially starts for me today and I am looking forward to playing as many matches as I can."

Sharapova has also been granted wildcards into the Madrid and Rome tournaments and she will need similar generosity from Roland Garros if she is to make the main draw of the French Open, where she is a two-time champion.

On Wednesday, the French Tennis Federation repeated that they will not make a decision until next month.

"There is a date which has been fixed. There is no reason to make an exception for Maria Sharapova," said FFT president Bernard Guidicelli.

"We will meet with the tournament director Guy Forget on May 15. The decision will be taken and communicated at 1900 (1700GMT) on Facebook on May 16.

"I know that there is strong expectation from the media and fans but we are not casting. This is not a rock-opera."

With the likes of Serena Williams, Victoria Azarenka and Petra Kvitova sidelined – and potential heir Eugenie Bouchard struggling – women's tennis needs pulling power and Sharapova ticks all the boxes for event organisers.

But many remain to be convinced.

Bouchard was quoted in an interview in Istanbul as describing her childhood idol as a "cheater".

World number five Simona Halep, the fourth seed in Stuttgart, believes that handing Sharapova wildcards sends completely the wrong signal.

"I can't support what the tournament director has done but in my opinion, for children and young players, it's not OK to help players who were banned for doping with wildcards," said the Romanian.

Washington D.C. 
Animal rights activists have been debating about the use of animals in biomedical research since long but scientists suggest improvements to animal testing protocols could boost credibility and usefulness.

Two leading scientists writing in the European Journal of Internal Medicine give their expert view of the importance of animal testing to medical progress and present ways it could be further improved to yield more useful clinical results.

"It cannot be stressed enough that animal studies have led to the production of drugs that have affected the epidemiology of human pathology, contributing to prolonging life. There is no magic formula at present to predict - at the preclinical level - the therapeutic value of a drug for people with a disease. Preclinical studies are needed in order to formulate hypotheses that justify clinical trials. Without these preliminary in vitro and in vivo studies in selected animal species, it would be unethical to test still unproven chemicals in humans," explains Silvio Garattini, MD, Founder and Director of the Mario Negri Institute for Pharmacological Research, Milan, Italy.

His co-author, Giuliano Grignaschi, PhD, head of the Animal Care Unit at the Mario Negri Institute and vice president of the Basel Declaration Society in Switzerland, which promotes information about animal testing, adds that "the pressure of public opinion, particularly of organized groups of 'animalists,' obliges preclinical and clinical scientists to come out of their 'ivory tower' to explain the complexity of translating research results from animals to man."

Vaccines against poliomyelitis, meningitis, and rotaviruses are excellent examples in which animal testing, and the translation from animals to man, have proved effective, as are a number of antibiotics and the recent agents against HIV and hepatitis C viruses.

However, the authors acknowledge that at the other extreme, there have been poor correlations between results in animals and man in several diseases such as stroke, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease, and they summarize several analyses that have set out to understand why results in animals and man differ in these cases.

The authors present four ways in which animal experiments could be improved in order to increase their probability of predicting useful clinical results.

First, studies need to be intensified and techniques developed to improve and reduce the use of animals following the 3R rule (Replace, Reduce, and Refine). These guiding principles underpin the humane use of animals in scientific research and any researcher planning to use animals in their research must first show why there is no alternative and what will be done to minimize numbers and suffering,

Second, rules developed to improve clinical trials should be incorporated into animal testing to minimize bias.

Third, research is needed to improve the translation of animal research to patients, they argue, pointing out that the National Institutes of Health (NIH) in the U.S. has recently launched a program to train preclinical scientists to plan their experimental trials better by applying the same rules as for clinical trials. "There is, however, a pressing need for responsibility in the scientific community, not only among scientists, but also in the editorial boards of journals and funding bodies to focus more on the quality of articles and research proposals dealing with animal investigation," they note.

Fourth, once bias has been taken care of, difficulties remain for each specific demand for therapy - symptomatic, preventive, or curative - of finding the animal species that best mimics the human condition. Animals with specific pathology such as diabetes, high cholesterol, and hypertension have helped scientists develop antidiabetic, hypocholesterolemic, and antihypertensive drugs, which have been effective in man and are widely used. More studies are needed in aged animals to mimic the condition of elderly people with co-morbidities that require several drugs. Different chemical mediators may be important tools for discovering new drugs once they have been found to exert similar effects in a given animal species and man.

"Limitations to the use of animals, particularly other than rodents, are an obstacle to obtaining a wider spectrum of activity across species which may help in deciding when a treatment is suitable for patients," says Dr Grignaschi. "Nevertheless, there is room for substantial improvement in the protocols of animal tests to boost their credibility and reproducibility.

"For the time being, animal models remain the best alternative given the limited usefulness of computer and in vitro models, and their use must continue, considering that patients cannot just wait for better tests to cure their suffering," concludes Prof. Garattini.

Washington D.C. 
U.S. President Donald Trump has released a tax plan that proposes to cut income tax rates, slash taxes for businesses and on overseas corporate profits returned to the country.

Touted as a 'landmark proposal', Trump's tax plan proposes to cut the U.S.'s individual income tax rate from 39.6 percent to 35 percent, and reduce the tax brackets from seven to three - 10 percent, 25 percent and 35 percent, reports the Guardian.

The tax plan was unveiled just days before Trump marks his 100th day in office on Saturday.

"We have a once in a generation opportunity to do something really big. This is about growing the economy, creating jobs." said Gary Cohn, Chief Economic Adviser to Trump.

Under the proposed plan, the corporate tax rate would drop from 35 percent to 15 percent.

The Trump administration also proposed tax relief for families with child and dependent care expenses.

Trump's tax plan would also double the standard deduction for married couples to USD 24,000 and repeal the estate tax.

In a joint statement, Senate Majority Leader Mitch McConnell and House Speaker Paul Ryan said, "The principles outlined by the Trump administration today will serve as critical guideposts for the Congress and administration as we work together to overhaul the American tax system and ensure middle-class families and job creators are better positioned for the 21st century economy."

Earlier, Treasury Secretary Steve Mnuchin described Trump's tax plan as "the biggest tax cut" and the "largest tax reform" in the U.S. history.

New Delhi 
Emaar India, the iconic brand and leading global property developer, has received the Occupancy Certificate for its LEED-certified Integrated IT Park Complex Digital Greens, located in Sector 61, Gurgaon.

The project is located on the highly anticipated Southern Peripheral road with easy connectivity to the international airport, Faridabad, Delhi and Manesar regions.

Digital Greens is spread across a sprawling 6.8 acres with a total built-up area of 1.25 million sq ft approximately. The eco-friendly complex has been designed by Singapore-based architect firm HOK with cutting edge technology, state-of-the-art infrastructure and facilities. The executive architect for the IT Park project is US-based Studio U+A Norr.

"We are happy to receive yet another Occupancy Certificate for our Projects and shall offer handover to our patrons shortly. This would be our fourth delivery in as many months. The realty market across the country is undergoing testing times, and achievement of these remarkable objectives is a testimony to our renewed efforts to fast track completion and handover of all ongoing projects to our customers," said CEO Emaar India, Sanjay Malhotra.

Prior to this, Emaar India has recently delivered The Palm Drive (second phase) and Emerald Hills in Gurugram, as well as The Avenues and Grace at Esplanade in Chennai.

Emaar India has been incorporating green building guidelines in the design and construction of its projects. Digital Greens is a highly energy and resource-efficient LEED-certified green building that would considerably reduce the carbon footprint of the project as well as its users.

The environmental-friendly project has features like contemporary style, use of environmentally sensitive construction material, high-quality finish and technologically advanced infrastructure to offer an ideal work-life experience and healthy environment.

Moreover, the project has integrated building management system, high speed elevators with Destination Control system and Automatic Rescue Device (ARD) system, centralized air-conditioning with high-efficiency chillers, double-glazed units for energy efficiency, noise and heat insulation, and efficient glass-to-glass distance for maximum natural light. Other features include power back-up, state-of-the-art life safety and security system, adequate parking spaces at ground and basement levels. 

NEW DELHI
Prime Minister Narendra Modi will launch on Thursday a regional air connectivity scheme under which the fares of flights will be capped at Rs 2500 per seat per hour.  Modi will flag off a flight from Shimla to Delhi to launch the ‘UDAN’ (Ude Desh Ka Aam Nagrik) scheme which is aimed at boosting regional connectivity. Simultaneously, flights will be launched on Kadapa– Hyderabad and the Nanded-Hyderabad sectors. ‘UDAN’ is a first-of-its-kind scheme globally to stimulate regional connectivity through a market-based mechanism, the PMO said in a tweet.

The founder of Wikipedia is starting a website he says will fight so-called fake news.

Jimmy Wales says his Wikitribune site will bring journalists and volunteer fact checkers together to stop the spread of false news stories.

"We want to make sure that you read fact-based articles that have a real impact in both local and global events," according to the group’s website.

The volunteer fact checkers’ role will be similar to how editors work on Wikipedia. Any changes will be reviewed by other fact checkers.

The site will also carry stories by professional journalists.

Unlike most news sites, Wikitribune says it will post full transcripts of interviews “to the maximum extent possible.”

"It takes professional, standards-based journalism, and incorporates the radical idea from the world of wiki that a community of volunteers can and will reliably protect the integrity of information," said Wales, according to CNN.

Money to fund the site will come from contributions as opposed to advertisements or subscriptions.

"[Fake news] is literally designed to show us what we want to see, to confirm our biases, and to keep us clicking at all cost," Wales said. "It fundamentally breaks the news."

Some experts as skeptical, saying the site may only appeal to journalists and people who read a lot of news.

"I wonder whether it will be able to scale up to make a significant impact on the information sphere, especially on social networks such as Facebook where the main problems of fake news and misinformation occur," saidCharlie Beckett, a professor at the London School of Economics, in an interview with CNN.

Wales’ Wikipedia has long battled criticism that it contains misleading or false information.

By Brent Lang, Carmel Dagan
Oscar-winning director Jonathan Demme died Wednesday in New York of cancer complications, his publicist told Variety. He was 73 years old.

Demme is best known for directing “The Silence of the Lambs,” the 1991 horror-thriller that was a box office smash, a critical triumph, and introduced moviegoers to Anthony Hopkins’ Hannibal Lecter, a charismatic serial with a yen for chianti, fava beans, and cannibalism. The story of a novice FBI analyst (Jodie Foster) on the trail of a murderer became only the third film in history to win Academy Awards in all the top five categories ( picture, actor, actress, director, and adapted screenplay), joining the ranks of “It Happened One Night” and “One Flew Over the Cuckoo’s Nest.”

Though he had his greatest success terrifying audiences, most of Demme’s work was looser and quirkier. In particular, he showed a great humanism and an empathy for outsiders in the likes of “Melvin and Howard,” the story of a service station owner who claimed to have been a beneficiary of Howard Hughes, and “Something Wild,” a screwball comedy about a banker whose life is turned upside down by a kooky woman. He also scored with “Married to the Mob” and oversaw “Stop Making Sense,” a documentary about the Talking Heads that is considered to be a seminal concert film.

Following “The Silence of the Lambs,” Demme used his clout to make “Philadelphia,” one of the first major studio films to tackle the AIDS crisis and a movie that won Tom Hanks his first Oscar for playing a gay lawyer.
The director most recently worked on an episode of the Fox police drama “Shots Fired,” which is scheduled to air on April 26 — the same day Demme’s death was announced. He also filmed the 2016 concert film “Justin Timberlake + the Tennessee Kids.” His most recent narrative feature was 2015’s “Ricki and the Flash,” starring Meryl Streep as an aging rocker who must return home to Indiana due to a family crisis. The film disappointed at the box office and reviews were muted.

After jumping on the CB radio craze with the under-appreciated indie “Handle With Care,” Demme came to the attention of Hollywood with the 1980 film “Melvin and Howard.” Both films starred Paul LeMat; Jason Robards co-starred as a bearded, bedraggled Hughes encountered by struggling Melvin Dumont, who helps Howard out — only to be left $156 million in a Hughes will of dubious authenticity. The film worked because it was not about Hughes but about Dumont, played by Paul Le Mat (one of Demme’s favorite actors). It drew three Oscar nominations, winning for best supporting actress (Mary Steenburgen) and original screenplay (Bo Goldman), while Robards also drew a nomination.

The 1984 film “Swing Shift,” a romantic dramedy set on the homefront during WWII and starring Goldie Hawn and Kurt Russell, was directed by Demme but taken out of his hands by the studio and recut, reportedly to make Hawn’s characterization more flattering. Director and star clashed during the production with Hawn wanting a more conventional love story with laughs and Demme preferring something with rougher edges.

Two years later, Demme rebounded with the New Wave-flavored indie comedy “Something Wild.” He drew an erotically anarchical performance from Melanie Griffith, as a brunette on the run, and coaxed an impressive debut from Ray Liotta as Griffith’s lunatic ex-boyfriend.

Demme had a way with actors, discovering new talent and allowing performers to stretch their muscles. His 1988 comedy “Married to the Mob,” starred Michelle Pfeiffer, replete with loud hair and a thick New York accent, in a performance that showed the actress’ range.  It also benefited from excellent supporting performances by Dean Stockwell as the Mafia boss and Mercedes Ruehl as his far fiercer wife. Stockwell earned an Oscar nomination.

In addition to “Stop Making Sense,” Demme did documentaries on the Pretenders, Bruce Springsteen and Neil Young, and he also directed quite a number of music videos, drawing a Grammy nomination in 1987 for best long form music video for “Sun City: Artists United Against Apartheid.”
Demme’s nonfiction work also dipped into politics and social issues, profiling the likes of Jimmy Carter and Nelson Mandela.  He made two documentaries about Haiti, 1988’s “Haiti Dreams of Democracy” and 2003’s critically acclaimed “The Agronomist.” Of the latter the New York Times said, “The turbulence that led to the removal of Jean-Bertrand Aristide from Haiti’s presidency gives ‘The Agronomist,’ a superb new documentary by Jonathan Demme, a melancholy timeliness. Its hero, Jean Dominique, embodies the fragile, perpetual hope that Haiti might someday nurture a just and decent political order.”

Demme’s commercial prowess waned in the late 1990s and early aughts. “Beloved,” a 1998 adaptation of Toni Morrison’s award-winning book, received some critical support, but was a massive bomb and failed to attract much Oscar attention. Then there was an ill-advised 2002 “Charade” remake “The Truth About Charlie,” which starred Mark Wahlberg and Thandie Newton and proved a disservice to the classic Stanley Donen original.

He also failed to convince critics that his 2004’s big-budget, high-profile remake of “The Manchurian Candidate” needed to be made. The film starred Denzel Washington, Liev Schreiber and Meryl Streep, which hit in the middle of a contentious presidential election between George W. Bush and John Kerry, but despite the political climate, it didn’t make much of a splash.

The 2008 film “Rachel Getting Married,” was a return to form for Demme, and served as an excellent vehicle for Anne Hathaway to demonstrate acting ability in a largely unsympathetic role of a young woman, out of rehab long enough to attend the wedding of the sister. Hathaway received her first Oscar nomination for the part.

Demme directed an adaptation of the Ibsen play “The Master Builder,” penned by and starring Wallace Shawn, in 2013. In 2015, in addition to “Ricki and the Flash,” he directed the docu-series “The New Yorker Presents,” bringing to life the iconic magazine.

Robert Jonathan Demme was born in Baldwin, Long Island, New York, and attended the University of Florida. Like John Sayles, he began his directing career in Roger Corman’s stable, helming women’s prison exploitation film “Caged Heat” in 1974; nostalgic road trip film “Crazy Mama,” starring Cloris Leachman, in 1975; and Peter Fonda action film “Fighting Mad” in 1976.

In 2006 Demme was presented with the National Board of Review’s Billy Wilder Award. Demme’s nephew, director Ted Demme, died in 2002 at age 38.

Demme was previously married to director-producer Evelyn Purcell. He is survived by second wife Joanne Howard and their three children: Ramona, Brooklyn and Jos.

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